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NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 177-184 doi: 10.1007/s11684-010-0038-1

Abstract: Nucleoside reverse transcriptase inhibitors (NRTIs) could damage the mitochondria by inhibiting the human

Keywords： nucleoside reverse transcriptase inhibitors     human immunodeficiency virus     mitochondrial DNA     D loop     mutation    

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Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11705-014-1454-6

Abstract: Previous studies have found that three peptide inhibitors (i.e., KLVFF, VVIA, and LPFFD) can inhibitHowever, atomic details of binding modes and binding affinities between these peptide inhibitors andAll inhibitors exhibit varied binding affinity to A , in which KLVFF has the highest binding affinityMM/PBSA analysis further revealed that different peptide inhibitors have different modes of interactionSpecific residue-based interactions between inhibitors and A were determined and compared for illustrating

Keywords： Alzheimer’s disease     amyloid β-protein     peptide inhibitors     protein-protein interaction     molecular    

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Synthesis of mono and bis-4-methylpiperidiniummethyl-urea as corrosion inhibitors for steel in acidic

Abbas TEIMOURI, Nasrin SOLTANI, Alireza Najafi CHERMAHINI

Frontiers of Chemical Science and Engineering 2011, Volume 5, Issue 1,   Pages 43-50 doi: 10.1007/s11705-010-0532-7

Abstract: Mono and bis-4-methylpiperidiniummethyl urea were synthesized, characterized and used as new corrosion inhibitorsPotentiodynamic polarization measurements showed that two inhibitors are mixed type.This reveals that inhibitive actions of inhibitors were mainly due to adsorption on mild steel surface

Keywords： corrosion inhibitors     mild steel     acidic medium     theoretical studies     DFT    

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Highly hydrophobic oil−water separation membrane: reutilization of waste reverse osmosis membrane

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 10,   Pages 1606-1615 doi: 10.1007/s11705-022-2200-0

Abstract: increasing applications of seawater desalination technology have led to the wide usage of polyamide reverseosmosis membranes, resulting in a large number of wasted reverse osmosis membranes.In this work, the base nonwoven layer of the wasted reverse osmosis membrane was successfully modifiedThis work might provide a new avenue for recycling the wasted reverse osmosis membrane used in oily wastewater

Keywords： oil–water separation     wasted reverse osmosis membrane     hydrophobic modification    

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Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 46-53 doi: 10.1007/s11684-010-0010-0

Abstract: So far, inhibitors specifically against each subfamilies of MAP kinase have been developed, while moreMost of the kinase inhibitors exert their functions in an ATP-competitive way or a non-ATP-competitiveFurther studies on the effective mechanism of the MAPK inhibitors and their therapeutic roles in thetreatment of diseases are helpful for the illumination of MAP kinase function, the development of novel inhibitors

Keywords： mitogen-activated protein kinase     drug target     inhibitor     signal transduction     disease    

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Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 24-31 doi: 10.1007/s11684-019-0679-7

Abstract: Immune checkpoint inhibitors are a promising strategy in the treatment of cancer, especially advancedHowever, not all patients are responsive to immune checkpoint inhibitors.of data, which allow researchers to explore responsive or resistant biomarkers of immune checkpoint inhibitors

Keywords： immune checkpoint blockade     sensitivity     resistance     data mining    

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Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 307-321 doi: 10.1007/s11684-022-0927-0

Abstract: The discovery of immune checkpoint inhibitors, such as PD-1/PD-L1 and CTLA-4, has played an importantwidely applied in clinical treatment, and they are inevitably used in combination with immune checkpoint inhibitorsClinical practice has revealed that antibiotics can weaken the therapeutic response to immune checkpoint inhibitorsStudies have shown that the gut microbiota is essential for the interaction between immune checkpoint inhibitorsThis review focuses on the interactions between immune checkpoint inhibitors and antibiotics, with an

Keywords： tumor immunotherapy     immune checkpoint inhibitor     antibiotics     gut microbiota     drug–drug interaction    

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Centrifuge experiments for shallow tunnels at active reverse fault intersection

Mehdi SABAGH, Abbas GHALANDARZADEH

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 3,   Pages 731-745 doi: 10.1007/s11709-020-0614-7

Abstract: Dip-slip surface faulting in reverse mechanism of 60-degree is modeled by a fault simulator box in aAccording to the observations, the modeled tunnels are vulnerable to reverse fault rupture and but the

Keywords： reverse fault rupture     continuous tunnel     geotechnical centrifuge     ground surface deformations     fragility    

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Advances in newly developing therapy for chronic hepatitis C virus infection

Paul J. Pockros

Frontiers of Medicine 2014, Volume 8, Issue 2,   Pages 166-174 doi: 10.1007/s11684-014-0334-2

Abstract:

Chronic hepatitis C virus (HCV) infection afflicts a reported 170 million people worldwide and is often complicated by cirrhosis and hepatocellular carcinoma. Morbidity and mortality are decreased with the successful treatment of chronic HCV infection. Increased understanding of the HCV has allowed further development of new direct-acting antiviral (DAA) agents against the HCV and has also allowed the development of IFN-free oral treatment regimens. In late 2013 the first nucleotide polymerase inhibitor regimen with RBV alone for genotypes 2/3 and in combination with a 12-week regimen of PEG-IFN+RBV for genotypes 1, 4 was approved for use in the US. A number of promising new DAA regimens which are IFN-free are in phase 3 development and the first will likely be approved for use in the US in 2014. The currently approved regimens are discussed in detail and currently available data on future regimens are reviewed herein.

Keywords： direct-acting antiviral (DAA)     nucleotide polymerase inhibitors     protease inhibitors    

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Self-healing polyamide reverse osmosis membranes with temperature-responsive intelligent nanocontainers

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 9,   Pages 1183-1195 doi: 10.1007/s11705-022-2287-3

Abstract: Improving the performance of reverse osmosis membranes remains great challenge to ensure excellent NaClnanocontainer has great potential as membrane-doping material for the targeted repair of polyamide reverse

Keywords： reverse osmosis     nanocontainer     self-healing     chlorine resistance     water permeability    

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DISCOVERY OF TRIKETONE-QUINOXALINE HYBRIDS AS POTENT HPPD INHIBITORS USING STRUCTURE-BASED DRUG DESIGN

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 1,   Pages 133-145 doi: 10.15302/J-FASE-2021401

Abstract: This study indicates that triketone-quinoxaline is a promising scaffold for discovering HPPD inhibitors

Keywords： herbicide / HPPD / inhibitor / quinoxaline / triketon    

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Mechanism of ethanol/water reverse separation through a functional graphene membrane: a molecular simulation

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 3,   Pages 347-357 doi: 10.1007/s11705-022-2246-z

Abstract: Reverse-selective membranes have attracted considerable interest for bioethanol production.However, to date, the reverse-separation performance of ethanol/water is poor and the separation mechanismPristine graphene (PG) exhibits reverse-selective behavior with higher ethanol fluxes than water, resultingThis study provides new insights into the reverse-selective mechanism of porous graphene membranes and

Keywords： reverse separation     graphene membrane     ethanol/water separation     molecular simulation    

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Tracing the impact of stack configuration on interface resistances in reverse electrodialysis by in situ

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 4, doi: 10.1007/s11783-021-1480-9

Abstract:

• RED performance and stack resistance were studied by EIS and LSV.

Keywords： Reverse electrodialysis     Electrochemical impedance spectroscopy     Concentration polarization     Spacer shadow    

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Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 7, doi: 10.1007/s11783-021-1497-0

Abstract:

• Nanoparticle incorporation and anti-biofouling grafting were integrated.

Keywords： Anti-biofouling grafting     Nanoparticle incorporation     Sterilization rates     Water flux     Water flux recovery    

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Efficient production of hydrogen peroxide in microbial reverse-electrodialysis cells coupled with thermolytic

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 9, doi: 10.1007/s11783-023-1708-y

Abstract:

● Appreciable H2O2 production rate was achieved in MRCs utilizing NH4HCO3 solutions.

Keywords： Microbial reverse-electrodialysis cell     Hydrogen peroxide production     Ammonium bicarbonate     Electrolysis    

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Title Author Date Type Operation

NRTIs’ effect on the sequence of mitochondrial DNA HV 2 in HIV infected patients

Ya-Song WU MD, PhD, Xin-Yue CHEN MD, Ying SHI PhD, Hao WU MD, De-Xi CHEN MD, PhD, Yu SUN MD, Fu-Jie ZHANG MD,

Journal Article

Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Journal Article

Synthesis of mono and bis-4-methylpiperidiniummethyl-urea as corrosion inhibitors for steel in acidic

Abbas TEIMOURI, Nasrin SOLTANI, Alireza Najafi CHERMAHINI

Journal Article

Highly hydrophobic oil−water separation membrane: reutilization of waste reverse osmosis membrane

Journal Article

Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?

Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,

Journal Article

Screening responsive or resistant biomarkers of immune checkpoint inhibitors based on online databases

Zhen Xiang, Yingyan Yu

Journal Article

Analysis of interactions of immune checkpoint inhibitors with antibiotics in cancer therapy

Journal Article

Centrifuge experiments for shallow tunnels at active reverse fault intersection

Mehdi SABAGH, Abbas GHALANDARZADEH

Journal Article

Advances in newly developing therapy for chronic hepatitis C virus infection

Paul J. Pockros

Journal Article

Self-healing polyamide reverse osmosis membranes with temperature-responsive intelligent nanocontainers

Journal Article

DISCOVERY OF TRIKETONE-QUINOXALINE HYBRIDS AS POTENT HPPD INHIBITORS USING STRUCTURE-BASED DRUG DESIGN

Journal Article

Mechanism of ethanol/water reverse separation through a functional graphene membrane: a molecular simulation

Journal Article

Tracing the impact of stack configuration on interface resistances in reverse electrodialysis by in situ

Journal Article

Preparation of reverse osmosis membrane with high permselectivity and anti-biofouling properties for

Journal Article

Efficient production of hydrogen peroxide in microbial reverse-electrodialysis cells coupled with thermolytic

Journal Article